India is set to become the 29th signatory of the US Reciprocal Defence Procurement Agreement (RDPA), unlocking access to the $850 billion US defense market and enhancing its defense manufacturing capabilities. This agreement, along with India’s “Make in India” initiative, aims to transform Indian defense firms into global players, evidenced by a remarkable increase in defense exports and production. However, challenges such as navigating the complex US procurement regulatory environment and maintaining cooperation amidst potential trade disputes remain. The RDPA is positioned to strengthen India’s strategic partnerships, particularly within the Quad, and could fundamentally reshape India’s role in global defense innovation and supply chains.